Biosensing with backscattering interferometry

The effect of hybridization-induced secondary structure alterations on RNA detection using backscattering interferometry

Backscattering interferometry (BSI) has been used to successfully monitor molecular interactions without labeling and with high sensitivity. These properties suggest that this approach might be useful for detecting biomarkers of infection. In this report, we identify interactions and characteristics of nucleic acid probes that maximize BSI signal upon binding the respiratory syncytial virus nuc...

Toward Rapid, High-Sensitivity, Volume-Constrained Biomarker Quantification and Validation using Backscattering Interferometry

Realizing personalized medicine, which promises to enable early disease detection, efficient diagnostic staging, and therapeutic efficacy monitoring, hinges on biomarker quantification in patient samples. Yet, the lack of a sensitive technology and assay methodology to rapidly validate biomarker candidates continues to be a bottleneck for clinical translation. In our first direct and quantitati...

Biosensing with T-ray spectroscopy

In the recent years, it has been shown that terahertz (or T-ray) spectroscopy is a versatile tool for biosensing and safety applications. This is due to the fact that the THz-spectra of many biomolecules show very characteristic, distinct spectroscopic features. Furthermore, most non-metallic packaging materials are nearly transparent in this frequency range (0.1 6 THz, 3 c m 1 200 cm 1 ) , so ...

Biosensing with Virus Electrode Hybrids.

Virus electrodes address two major challenges associated with biosensing. First, the surface of the viruses can be readily tailored for specific, high affinity binding to targeted biomarkers. Second, the viruses are entrapped in a conducting polymer for electrical resistance-based, quantitative measurement of biomarker concentration. To further enhance device sensitivity, two different ligands ...

Electrochemical Biosensing with Carbon Nanotubes